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MEXICO;will HIV drugs have a long-term impact on the brain?
New diagnoses of HIV-associated neurocogntive disease fell up to 50 percent after people with HIV in countries with access to medications started taking potent antiretroviral combiantions, but overall neurocognitive disease prevalance keeps climbing in HIV positive people.
Brain cell research from the University of Hawaii presented at AIDS 2008 suggests why prevlence of HIV dementia remains so high: certain antiretrovirals- specifically nucleoside analogues may upset the balance of mitochondria, the cell's powerhouse.
The Hawaiian researchers found signals of mitochondrial malfunction in neurons (a type of brain cell) exposed to AZT, 3TC and the protease inhbitors lopinavir/ritonavir compared with unexposed neurons.
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